Solid Organ Transplantation
Dartmouth-Hitchcock Medical Center
The Dartmouth Program in Transplantation: Precision Medicine Comes of Age.
Immunosuppression for organ transplantation should be based upon an individual's needs. Each individual's unique physiology, pharmacology, and immune status require precision medicine. Dr. Michael Chobanian provides an overview and discusses why monotherapy works. Until the late 1990s, the concept of using a single agent was never broached and rejection rates were 100%. In the late 70s and early 80s, two drugs were administered; in 1983, it was three drugs. DHMC developed a process called monotherapy, giving patients one drug. The program is unique because the reduction rates have been dramatically reduced to virtually none.